Atrial Fibrillation

CHROMOSOME ONE(1)

KCNN3 153080977 rs13376333 C or T CC
MAF/MinorAlleleCount: T=0.221/483
P=6.3×10−12
Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/

AGT 228912417 rs699 A or G AA
MAF/MinorAlleleCount: A=0.339/741
FBAT-P =.044
We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG).
http://www.sciencedirect.com/science/article/pii/S0022073609005378

CHROMOSOME TWO(2)

C2orf86 63607779 rs2421954 C or T TT
MAF/MinorAlleleCount: C=0.379/829
FBAT-P=1.51E-04 LOC51057
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/


CHROMOSOME THREE(3)

intergenic 110400929 rs1163397 C or T TT=AA
MAF/MinorAlleleCount: C=0.388/850
FBAT-P=1.78E-04
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/

CD200 113538529 rs10511311 A or T AA
MAF/MinorAlleleCount: T=0.238/520
P= 4.5 × 10-5
AF,rs10511311 in CD200, p = 4.5 × 10 -5 ;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/

CHROMOSOME FOUR(4)

USO1 76924038 rs324735 A or T TT
MAF/MinorAlleleCount: A=0.292/638
FBAT-P=9.98E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/

intergenic 111929618 rs2200733 C or T CC
MAF/MinorAlleleCount: T=0.270/591
Single nucleotide polymorphism (SNP) rs2200733 was associated with AF in all four cohorts, with odds ratios (ORs) ranging from 1.37 in Rotterdam [95% confidence interval (CI) 1.18–1.59; P = 3.1 × 10−5] to 2.52 in AFNet (95% CI 2.22–2.8; P=1.8 × 10−49).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663727/table/EHN578TB2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663727/
http://www.nature.com/nature/journal/v448/n7151/abs/nature06007.html


intergenic 111937516 rs6843082 A or G GG
MAF/MinorAlleleCount:G=0.408/892
P=2.5×10−28
The most significant SNP at this locus was rs6843082 (OR 2.03, 95% CI, 1.79–2.30; P=2.5×10−28,PITX2
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/

intergenic 111940210 rs10033464 G or T TT
MAF/MinorAlleleCount:T=0.163/357
A meta-analysis of the current and prior AF studies revealed an OR of 1.90 (95% CI 1.60–2.26; P = 3.3 × 10−13) for rs2200733 and of 1.36 (95% CI 1.26–1.47; P = 6.7 × 10−15) for rs10033464.
http://eurheartj.oxfordjournals.org/content/30/7/813.full
http://www.nature.com/nature/journal/v448/n7151/abs/nature06007.html
http://www.snpedia.com/index.php/Rs10033464(T;T)

CHROMOSOME ELEVEN(11)

intergenic 97372875 rs4590838 C or T CC
MAF/MinorAlleleCount: T=0.187/409
GEE-P=4.03E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387

CNTN5 98998383 rs10501920 C or G CC
MAF/MinorAlleleCount: G=0.149/325
GEE-P=9.40E-06
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/


CHROMOSOME TWELVE(12)

rs1427828
intergenic 88286630 rs1427828 C or G CC=GG
MAF/MinorAlleleCount: C=0.499/1091
FBAT-P=4.58E-05 DUSP6
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/

CHROMOSOME FOURTEEN(14)

RAD51L1 67747245 rs1298340 C or G GG
MAF/MinorAlleleCount: C=0.126/276
FBAT-P=7.40E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/

RAD51L1 67769347 rs1314913 C or T CC
MAF/MinorAlleleCount: T=0.108/236
FBAT-P=5.53E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/


CHROMOSOME SIXTEEN(16)

ZFHX3 71586661 rs7193343 C or T CC
MAF/MinorAlleleCount:T=0.311/68
P = 1.4x10-10
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke-A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4  10-10).
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
http://www.nature.com/ng/journal/v41/n8/full/ng.417.html
Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518320/

CHROMOSOME TWENTY(20)


intergenic 45858983 rs13038095 G or T GG
MAF/MinorAlleleCount:T=0.103/226
P=1.1×10−8  SULF2
A third SNP, rs13038095 on chromosome 20q13, also exceeded genome-wide significance (OR 1.61, 95% CI 1.37–1.91, p=1.1×10−8)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0023215/full

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For genotype-phenotype association analyses, we assumed an additive-allele model of inheritance and we conducted association tests using regression models with generalized estimating equations (GEE), as well as family-based association testing using FBAT.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/