Wednesday, May 9, 2012
Monday, May 7, 2012
Saturday, February 4, 2012
Profile
MEDICAL FACTS:
My gallbladder died-emergency removal
Gallstones-My risk=11.1%=1.58x7.0%Typ.
Hypertriglyceridemia [started decade ago], yet my data says I have typical odds:
rs964184-CC
Diagnosed as bipolar for almost two decades and meds made my high stress career liveable,
but my data says I have reduced odds:
rs4948418- CC
True Believers think:
1.Large segment sizes are passed intact and are proof we have detectable cousins.
2.Segments are tested and can be detected in 23andMe raw data.
3.They are doing a public service when they stalk others to proselytize and/or intimidate
them with harassment.
4.I care about their opinions even when Iam mostly revolted by them. manipulative and
abusive stalking of me on every post, including those where I originated the topic.
5.Consider it their duty to derail the posts and topics of with whom they disagree with
personal attacks and irrelevant off topic provocations.
Invisible Pink Unicorn in its Natural Habitat
http://www.facebook.com/photo.php?fbid=10150538693581457
With the Hopes that our World is built on they were utterly out of touch,
They denied that the Moon was Stilton; they denied she was even Dutch;
They denied that Wishes were Horses; they denied that a Pig had Wings;
So we worshipped the Gods of the Market Who promised these beautiful things.
Rudyard Kipling-The Gods of the Copybook Headings
Do not try to convince the True Believers.
This is my list to remind myself not to respond to their provoking remarks:
thetick:
fauxdk:
AndreaBadger:
GeeBee of Bavaria:
Geneadict:
altai volk:
Maureen Higgins Markov:
Tanaquil:
Glenn N.:
MMaddi:
Hobson, Hueston, Little, Massey, McConnell, McDonald, Montgomery, Moore, Norwood,
Reinholds, Reynolds, Rucker, Scharf, Shurvington, Woods, Work
Virginia, Scotland, Kent, England, Ireland, Germany, France, Ireland, Isle of Sky,
NC,&Virginia.
Lillian Rucker-AR
Susan Willie Caldoni Saffroni Little-AR
Susan Childress-AR
Susan Elvina Childress-GA
Sarah Massey-NC
Sarah Work-SC
Margaret [Unknown]-VA
This is a reader's digest version of my maternal lineage:
http://webspace.webring.com/people/tu/um_910/MOORE.HT
Type 2 Diabetes:My Risk=25.3%=.98x25.7% Typical risk
I have T2D/Type II Diabetes and one maternal aunt who has it. It did not start until my
mid-50s. I retired from 26 years of working in corrections, which kept me physically
active.
I have hypertriglerides and we have them under control, which may be why my
mother/aunts were affected with late onset AD. Diet does not seem to work. Meds do not
seem to work. I may have to exercise more.
is already public with the NCIB and I am an open book on my medical history.
I am diagnosed and treated for being bipolar. The True Believers who have not yet
admitted and gotten treatment are a pain.
http://www.facebook.com/media/set/?set=a.427524841456.204572.637766456
http://www.facebook.com/groups/HaplogroupJ1/
http://en.wikipedia.org/wiki/User:JohnLloydScharf/J1draft
http://www.facebook.com/groups/213733318644557/
http://www.ncbi.nlm.nih.gov/nuccore/JN020360
HVR1 differences from CRS:16519C
HVR2 differences from CRS:263G,315.1C
CR differences from CRS:750G,1438G,4769G,6776C,7148C, 8860G,15326G,15519C
My mtDNA Fasta File
http://testing-johnlloydscharf.blogspot.com/2011/12/my-mtdna.html
My mtDNA Data Processed
http://testing-johnlloydscharf.blogspot.com/2011/12/my-ydna.html
X STRS:
http://testing-johnlloydscharf.blogspot.com/2011/12/my-x-str-results.html
Autosomal STRS:
http://testing-johnlloydscharf.blogspot.com/2011/12/my-autosomal-str-results.html
Notes On My 23andMe Raw Data
http://testing-johnlloydscharf.blogspot.com/2011/12/notes-on-my-23andme-raw-data.html
My mtDNA haplogroup/haplotype:
http://www.facebook.com/photo.php?fbid=10150258318196457
My mtDNA disease profile:
http://www.facebook.com/photo.php?fbid=10150437948586457
My yDNA haplotype
http://www.facebook.com/photo.php?fbid=10150258318201457
My yDNA haplogroup
http://www.facebook.com/photo.php?fbid=10150258318206457
My yDNA STRs
http://www.facebook.com/photo.php?fbid=10150256641206457
http://www.facebook.com/photo.php?fbid=10150304085646457
My autosomal STRs
http://www.facebook.com/photo.php?fbid=10150266430616457
My X-STRs
http://www.facebook.com/photo.php?fbid=10150256652721457
https://www.23andme.com/you/community/guidelines/
23andMe kit number:
GED M211533
GED M083415
GED Kit Number: F125649
FTDNA Kit Number: 125649A
My raw data at:
http://opensnp.org/users/141
Process it at one of the following.
http://www.math.mun.ca/~dapike/FF23utils/
http://esquilax.stanford.edu/
Database for Autism:
http://autismkb.cbi.pku.edu.cn/
List of SNP-trait associations
About Me
Tiffany at 23andMe Customer Service (Tiffany B.) wrote:Dec 20, 2011
(6 hours ago)
John,
We have suspended your Community posting privileges effective immediately. Your recent posts are in violation of the Terms of Service agreement as well as our Community Guidelines. See https://www.23andme.com/about/tos/and https://www.23andme.com/you/community/guidelines/
Please note that you still have the ability to send and receive messages and invitations. Also, this revocation does not affect access to your data or account. Should we receive reports from other users that you are abusing the messaging system, that privilege will also be terminated immediately without notice.
Let me know if you have any questions.
Sincerely,
Tiffany
My gallbladder died-emergency removal
Gallstones-My risk=11.1%=1.58x7.0%Typ.
Hypertriglyceridemia [started decade ago], yet my data says I have typical odds:
rs964184-CC
Diagnosed as bipolar for almost two decades and meds made my high stress career liveable,
but my data says I have reduced odds:
rs4948418- CC
True Believers think:
1.Large segment sizes are passed intact and are proof we have detectable cousins.
2.Segments are tested and can be detected in 23andMe raw data.
3.They are doing a public service when they stalk others to proselytize and/or intimidate
them with harassment.
4.I care about their opinions even when Iam mostly revolted by them. manipulative and
abusive stalking of me on every post, including those where I originated the topic.
5.Consider it their duty to derail the posts and topics of with whom they disagree with
personal attacks and irrelevant off topic provocations.
Invisible Pink Unicorn in its Natural Habitat
http://www.facebook.com/photo.php?fbid=10150538693581457
With the Hopes that our World is built on they were utterly out of touch,
They denied that the Moon was Stilton; they denied she was even Dutch;
They denied that Wishes were Horses; they denied that a Pig had Wings;
So we worshipped the Gods of the Market Who promised these beautiful things.
Rudyard Kipling-The Gods of the Copybook Headings
Do not try to convince the True Believers.
http://www.law.cornell.edu/uscode/usc_sec_42_00001320---d006-.html
http://www.fbi.gov/atlanta/press-releases/2011/fake-doctor-sentenced-for-health-care-fraud-and-criminal-hipaa-violationsThis is my list to remind myself not to respond to their provoking remarks:
thetick:
fauxdk:
AndreaBadger:
GeeBee of Bavaria:
Geneadict:
altai volk:
Maureen Higgins Markov:
Tanaquil:
Glenn N.:
MMaddi:
DNFTT
Family Surnames
Beauchamp, Bird, Blythe, Carruthers, Childress, Ehart, Fielding, Gowder, Hall, Headen, Hobson, Hueston, Little, Massey, McConnell, McDonald, Montgomery, Moore, Norwood,
Reinholds, Reynolds, Rucker, Scharf, Shurvington, Woods, Work
Family Locations
Oregon, Washington, Kentucky, Arkansas, Texas, Georgia, South Carolina, North Carolina, Virginia, Scotland, Kent, England, Ireland, Germany, France, Ireland, Isle of Sky,
Geographic Facts:
Father-orphaned in Denver;lived in Nebraska. Mother born Arkansas;ancestry in KY, GA, SC, NC,&Virginia.
My maternal lineage is, starting with my mother:
Noda Moore-ARLillian Rucker-AR
Susan Willie Caldoni Saffroni Little-AR
Susan Childress-AR
Susan Elvina Childress-GA
Sarah Massey-NC
Sarah Work-SC
Margaret [Unknown]-VA
This is a reader's digest version of my maternal lineage:
http://webspace.webring.com/people/tu/um_910/MOORE.HT
Diagnosed Type II Diabetes though my data say I have average risk:
rs7903146-CTType 2 Diabetes:My Risk=25.3%=.98x25.7% Typical risk
I have T2D/Type II Diabetes and one maternal aunt who has it. It did not start until my
mid-50s. I retired from 26 years of working in corrections, which kept me physically
active.
I have hypertriglerides and we have them under control, which may be why my
mother/aunts were affected with late onset AD. Diet does not seem to work. Meds do not
seem to work. I may have to exercise more.
All my med. history is documented with my health insurance company and my offspring are
few, so I am willing to participate in any research. My full genome sequence for my mtDNA is already public with the NCIB and I am an open book on my medical history.
I am diagnosed and treated for being bipolar. The True Believers who have not yet
admitted and gotten treatment are a pain.
MY DNA MADE PUBLIC:
I am J1c3d yDNA and H3 mtDNA per FTDNA.These are my places for data on my DNA:
http://www.snpedia.com/index.php/User:JohnLloydScharfhttp://www.facebook.com/media/set/?set=a.427524841456.204572.637766456
http://www.facebook.com/groups/HaplogroupJ1/
Haplogroup J1c3d-P58+ M267+ L147.1+ M369- M368- M367- L65.2- L222.2- L174-
http://testing-johnlloydscharf.blogspot.com/2011/12/my-mtdna.htmlhttp://en.wikipedia.org/wiki/User:JohnLloydScharf/J1draft
http://www.facebook.com/groups/213733318644557/
Haplogroup - H3
http://en.wikipedia.org/wiki/User:JohnLloydScharf/Haplogroup_H3_(mtDNA)http://www.ncbi.nlm.nih.gov/nuccore/JN020360
HVR1 differences from CRS:16519C
HVR2 differences from CRS:263G,315.1C
CR differences from CRS:750G,1438G,4769G,6776C,7148C, 8860G,15326G,15519C
My mtDNA Fasta File
http://testing-johnlloydscharf.blogspot.com/2011/12/my-mtdna.html
My mtDNA Data Processed
http://testing-johnlloydscharf.blogspot.com/2011/12/my-ydna.html
X STRS:
http://testing-johnlloydscharf.blogspot.com/2011/12/my-x-str-results.html
Autosomal STRS:
http://testing-johnlloydscharf.blogspot.com/2011/12/my-autosomal-str-results.html
Notes On My 23andMe Raw Data
http://testing-johnlloydscharf.blogspot.com/2011/12/notes-on-my-23andme-raw-data.html
My mtDNA haplogroup/haplotype:
http://www.facebook.com/photo.php?fbid=10150258318196457
My mtDNA disease profile:
http://www.facebook.com/photo.php?fbid=10150437948586457
My yDNA haplotype
http://www.facebook.com/photo.php?fbid=10150258318201457
My yDNA haplogroup
http://www.facebook.com/photo.php?fbid=10150258318206457
My yDNA STRs
http://www.facebook.com/photo.php?fbid=10150256641206457
http://www.facebook.com/photo.php?fbid=10150304085646457
My autosomal STRs
http://www.facebook.com/photo.php?fbid=10150266430616457
My X-STRs
http://www.facebook.com/photo.php?fbid=10150256652721457
https://www.23andme.com/you/community/guidelines/
23andMe kit number:
GED M211533
GED M083415
GED Kit Number: F125649
FTDNA Kit Number: 125649A
My raw data at:
http://opensnp.org/users/141
Process it at one of the following.
http://www.math.mun.ca/~dapike/FF23utils/
http://esquilax.stanford.edu/
Database for Autism:
http://autismkb.cbi.pku.edu.cn/
List of SNP-trait associations
On FTDNA, my shared cM runs from 20.77cM to 66.02cM and includes 138 individuals.
23andM for the same range of 20.77cm to 66.02cM in RF, it includes 41 individuals.About Me
Tiffany at 23andMe Customer Service (Tiffany B.) wrote:Dec 20, 2011
(6 hours ago)
John,
We have suspended your Community posting privileges effective immediately. Your recent posts are in violation of the Terms of Service agreement as well as our Community Guidelines. See https://www.23andme.com/about/tos/and https://www.23andme.com/you/community/guidelines/
Please note that you still have the ability to send and receive messages and invitations. Also, this revocation does not affect access to your data or account. Should we receive reports from other users that you are abusing the messaging system, that privilege will also be terminated immediately without notice.
Let me know if you have any questions.
Sincerely,
Tiffany
Sunday, January 22, 2012
Atrial Fibrillation
CHROMOSOME ONE(1)
KCNN3 153080977 rs13376333 C or T CC
MAF/MinorAlleleCount: T=0.221/483
P=6.3×10−12
Common Variants in KCNN3 are Associated with Lone Atrial Fibrillation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
AGT 228912417 rs699 A or G AA
MAF/MinorAlleleCount: A=0.339/741
FBAT-P =.044
We observed significant association between tagging-SNP rs699 (M235T), located in exon 2 of the AGT gene, and AF. The AA genotype of rs699 increased the risk of AF by 70% (95% confidence interval, 1.01-2.85; P = .044) under a recessive model (AA vs AG + GG).
http://www.sciencedirect.com/science/article/pii/S0022073609005378
CHROMOSOME TWO(2)
C2orf86 63607779 rs2421954 C or T TT
MAF/MinorAlleleCount: C=0.379/829
FBAT-P=1.51E-04 LOC51057
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
CHROMOSOME THREE(3)
intergenic 110400929 rs1163397 C or T TT=AA
MAF/MinorAlleleCount: C=0.388/850
FBAT-P=1.78E-04
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
CD200 113538529 rs10511311 A or T AA
MAF/MinorAlleleCount: T=0.238/520
P= 4.5 × 10-5
AF,rs10511311 in CD200, p = 4.5 × 10 -5 ;
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
CHROMOSOME FOUR(4)
USO1 76924038 rs324735 A or T TT
MAF/MinorAlleleCount: A=0.292/638
FBAT-P=9.98E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
intergenic 111929618 rs2200733 C or T CC
MAF/MinorAlleleCount: T=0.270/591
Single nucleotide polymorphism (SNP) rs2200733 was associated with AF in all four cohorts, with odds ratios (ORs) ranging from 1.37 in Rotterdam [95% confidence interval (CI) 1.18–1.59; P = 3.1 × 10−5] to 2.52 in AFNet (95% CI 2.22–2.8; P=1.8 × 10−49).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663727/table/EHN578TB2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663727/
http://www.nature.com/nature/journal/v448/n7151/abs/nature06007.html
intergenic 111937516 rs6843082 A or G GG
MAF/MinorAlleleCount:G=0.408/892
P=2.5×10−28
The most significant SNP at this locus was rs6843082 (OR 2.03, 95% CI, 1.79–2.30; P=2.5×10−28,PITX2
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
intergenic 111940210 rs10033464 G or T TT
MAF/MinorAlleleCount:T=0.163/357
A meta-analysis of the current and prior AF studies revealed an OR of 1.90 (95% CI 1.60–2.26; P = 3.3 × 10−13) for rs2200733 and of 1.36 (95% CI 1.26–1.47; P = 6.7 × 10−15) for rs10033464.
http://eurheartj.oxfordjournals.org/content/30/7/813.full
http://www.nature.com/nature/journal/v448/n7151/abs/nature06007.html
http://www.snpedia.com/index.php/Rs10033464(T;T)
CHROMOSOME ELEVEN(11)
intergenic 97372875 rs4590838 C or T CC
MAF/MinorAlleleCount: T=0.187/409
GEE-P=4.03E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387
CNTN5 98998383 rs10501920 C or G CC
MAF/MinorAlleleCount: G=0.149/325
GEE-P=9.40E-06
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
CHROMOSOME TWELVE(12)
rs1427828
intergenic 88286630 rs1427828 C or G CC=GG
MAF/MinorAlleleCount: C=0.499/1091
FBAT-P=4.58E-05 DUSP6
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
CHROMOSOME FOURTEEN(14)
RAD51L1 67747245 rs1298340 C or G GG
MAF/MinorAlleleCount: C=0.126/276
FBAT-P=7.40E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
RAD51L1 67769347 rs1314913 C or T CC
MAF/MinorAlleleCount: T=0.108/236
FBAT-P=5.53E-05
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
CHROMOSOME SIXTEEN(16)
ZFHX3 71586661 rs7193343 C or T CC
MAF/MinorAlleleCount:T=0.311/68
P = 1.4x10-10
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke-A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 10-10).
A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
http://www.nature.com/ng/journal/v41/n8/full/ng.417.html
Atrial Natriuretic Peptide Frameshift Mutation in Familial Atrial Fibrillation
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518320/
CHROMOSOME TWENTY(20)
intergenic 45858983 rs13038095 G or T GG
MAF/MinorAlleleCount:T=0.103/226
P=1.1×10−8 SULF2
A third SNP, rs13038095 on chromosome 20q13, also exceeded genome-wide significance (OR 1.61, 95% CI 1.37–1.91, p=1.1×10−8)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/table/T2/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871387/
http://onlinelibrary.wiley.com/doi/10.1002/9780470015902.a0023215/full
===========================================================
For genotype-phenotype association analyses, we assumed an additive-allele model of inheritance and we conducted association tests using regression models with generalized estimating equations (GEE), as well as family-based association testing using FBAT.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995607/
Tuesday, January 3, 2012
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